2024
Scientific Publication

The epidemiological benefit of pyrethroid–pyrrole insecticide treated nets against malaria: an individual-based malaria transmission dynamics modelling study

Authors: Prof Thomas S Churcher, PhDa,* thomas.churcher@imperial.ac.uk ∙ Isaac J Stopard, PhDa,* ∙ Arran Hamlet, PhDa,* ∙ Dominic P Dee, MDa ∙ Antoine Sanou, PhDb ∙ Prof Mark Rowland, PhDc ∙ Moussa W Guelbeogo, PhDb ∙ Basiliana Emidi, PhDd ∙ Jacklin F Mosha, PhDd ∙ Joseph D Challenger, PhDa ∙ Adrian Denz, PhDa ∙ Andrew Glover, PhDa ∙ Giovanni D Charles, PhDa ∙ Emma L Russell, PhDa ∙ Rich Fitzjohn, PhDa ∙ Pete Winskill, PhDa ∙ Christen Fornadel, PhDe ∙ Tom Mclean, PhDe ∙ Peder Digref ∙ Joseph Wagman, PhDf ∙ Frank Mosha, PhDd ∙ Jackie Cook, PhDc ∙ Martin C Akogbéto, PhDg ∙ Prof Luc S Djogbenou, PhDh,i ∙ Prof Hilary Ranson, PhDi ∙ Prof Philip McCall, PhDi ∙ Alphaxard Manjurano, PhDd ∙ Sagnon N’Falé, PhDb ∙ Natacha Protopopoff, PhDc,d ∙ Manfred Accrombessi, PhDc ∙ Corine Ngufor, PhDc,g ∙ Geraldine Foster, PhDi ∙ Ellie Sherrard-Smith, PhDa

Abstract

Insecticide treated nets (ITNs) are the most important malaria prevention tool in Africa but the rise of pyrethroid resistance in mosquitoes is likely impeding control. WHO has recommended a novel pyrethroid–pyrrole ITN following evidence of epidemiological benefit in two cluster-randomised, controlled trials (CRTs). It remains unclear how effective more costly pyrethroid–pyrrole ITNs are compared with other tools, or whether they should be deployed when budgets are limited. We aimed to compare the epidemiological impact and cost-effectiveness of the mass distribution of pyrethroid–pyrrole ITNs relative to other ITNs over 3 years in different African settings.

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