2024
Scientific Publication

The effect of next-generation, dual-active-ingredient, long-lasting insecticidal net deployment on insecticide resistance in malaria vectors in Benin: results of a 3-year, three-arm, cluster-randomised, controlled trial

Authors: Arthur Sovi, PhD â Constantin J Adoha, MSc â Boulais Yovogan, MSc â Chad L Cross, PhD â Dominic P Dee, MSc â Alphonse Keller Konkon, PhD â Aboubakar Sidick, MSc â Manfred Accrombessi, PhD â Minassou Juvenal Ahouandjinou, MSc â Razaki Ossè, PhD â Edouard Dangbénon, MSc â Linda Towakinou, BSc â Clément Agbangla, PhD â Germain Gil Padonou, MSc â Thomas S Churcher, PhD â Corine Ngufor, PhD â Jackie Cook, PhD â Natacha Protopopoff, PhD â Martin C Akogbéto â Prof Louisa A Messenger, PhD

Abstract

Insecticide resistance among malaria vector species now occurs in 84 malaria-endemic countries and territories worldwide. Novel vector-control interventions, including long-lasting insecticidal nets (LLINs) that incorporate new active ingredients with distinct modes of action, are urgently needed to delay the evolution and spread of resistance and to alleviate reversals in malaria-control gains. We aimed to assess the longitudinal effect of two dual-active-ingredient LLINs on insecticide resistance during a cluster-randomised, controlled trial in Benin.

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