Bold Science. African-Led. Impact-Driven
Overview
The World Health Organization (WHO) recommended the rotation of insecticides for indoor residual spraying (IRS) as a strategy for managing insecticide resistance in malaria vectors. New IRS insecticides with novel modes of action, to which vectors were largely susceptible, were needed for improved control of resistant vector populations and for effective IRS rotation strategies. One such newly developed insecticide for vector control demonstrated (VECTRON T500) potential to control pyrethroid-resistant malaria vectors in laboratory and semi-field experimental hut studies.
Project Description
CREC/LSHTM evaluated this VECTRON T500 in a community trial conducted in southern Benin, assessing its efficacy and residual activity against pyrethroid-resistant malaria vectors in comparison to Fludora® Fusion.
The evaluation included:
Assessment of the impact of community IRS application on vector density, vector longevity, vector infectivity, and entomological inoculation rate (EIR) Assessment of the residual activity of the new IRS product applied on household walls Assessment of its operational feasibility and community acceptance in Benin
The trial started in 2020 and ran until 2022. The IRS products were applied in approximately 9,000 households organised into 16 clusters.
CREC/LSHTM worked in collaboration with key local and national partners, including CREC, the National Malaria Control Programme (NMCP), VectorLink, and the University of Abomey-Calavi.
